Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 78409..78968 Replicon plasmid pMB8093_2
Accession NZ_CP103572
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag M5S79_RS24315 Protein ID WP_000421257.1
Coordinates 78693..78968 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag M5S79_RS24310 Protein ID WP_001178089.1
Coordinates 78409..78693 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS24290 (M5S79_24290) 73595..74215 - 621 WP_000176497.1 DUF1449 family protein -
M5S79_RS24295 (M5S79_24295) 74482..75147 - 666 WP_000154143.1 hypothetical protein -
M5S79_RS24300 (M5S79_24300) 75288..75929 - 642 WP_000335846.1 transcription termination/antitermination NusG family protein -
M5S79_RS24305 (M5S79_24305) 76632..77504 + 873 WP_000729440.1 incFII family plasmid replication initiator RepA -
M5S79_RS24310 (M5S79_24310) 78409..78693 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
M5S79_RS24315 (M5S79_24315) 78693..78968 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S79_RS24320 (M5S79_24320) 79074..79277 + 204 Protein_86 hypothetical protein -
M5S79_RS24325 (M5S79_24325) 79546..79812 - 267 WP_000627835.1 hypothetical protein -
M5S79_RS24330 (M5S79_24330) 79812..80288 - 477 WP_016235982.1 hypothetical protein -
M5S79_RS24335 (M5S79_24335) 80344..80946 - 603 WP_000517689.1 ProQ/FINO family protein -
M5S79_RS24340 (M5S79_24340) 81300..82646 + 1347 WP_016235981.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..94670 94670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T255630 WP_000421257.1 NZ_CP103572:78693-78968 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT255630 WP_001178089.1 NZ_CP103572:78409-78693 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References