Detailed information of TA system TA025563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2119051..2119585
• Replicon: chromosome
• Accession: NC_015850
• Organism: Acidithiobacillus caldus SM-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ATC_RS10340
• Protein ID: WP_041636484.1
• Coordinates: 2119304..2119585 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F9ZR25
• Locus tag: ATC_RS10335
• Protein ID: WP_014003226.1
• Coordinates: 2119051..2119317 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATC_RS10310	2114764..2114964	-	201	WP_148262222.1	hypothetical protein	-
ATC_RS10315	2114964..2115557	-	594	WP_041636480.1	hypothetical protein	-
ATC_RS10320	2115547..2115909	-	363	WP_014003221.1	hypothetical protein	-
ATC_RS10325	2115902..2116942	-	1041	WP_014003222.1	ParB N-terminal domain-containing protein	-
ATC_RS17095	2118334..2118597	-	264	WP_148262223.1	hypothetical protein	-
ATC_RS10330	2118645..2118866	+	222	WP_041636482.1	hypothetical protein	-
ATC_RS10335	2119051..2119317	+	267	WP_014003226.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ATC_RS10340	2119304..2119585	+	282	WP_041636484.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ATC_RS10345	2119692..2120918	-	1227	WP_014003228.1	IS110 family transposase	-
ATC_RS17100	2121610..2121774	-	165	WP_148262224.1	helix-turn-helix domain-containing protein	-
ATC_RS16585	2121737..2122039	-	303	WP_082177438.1	primase C-terminal domain-containing protein	-
ATC_RS17400	2122228..2122365	+	138	WP_187288623.1	hypothetical protein	-
ATC_RS10355	2122415..2123371	+	957	WP_014003230.1	hypothetical protein	-
ATC_RS10360	2123399..2124211	+	813	WP_014003231.1	SET domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2119692..2120918	1226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-79)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.31 Da
• Isoelectric Point: 8.9184

>T25563 WP_041636484.1 NC_015850:2119304-2119585 [Acidithiobacillus caldus SM-1]
MRTIDRSSAFKRDYRRETKGRHRATLDEDFKRVLVALATDQPLDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDADTL
KLARLGSHSELFD

Nucleotide

• Length: 282 bp

>T25563 NC_015850:2119304-2119585 [Acidithiobacillus caldus SM-1]
ATGCGGACGATTGATCGCTCCTCAGCGTTCAAACGCGACTACAGGCGGGAGACCAAAGGCCGACACCGCGCCACGCTCGA
TGAAGATTTCAAGCGGGTTCTGGTTGCGCTGGCGACCGATCAACCTTTGGATGCGCGCTACCGCGACCACGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAATGCCACATCAAGCCCGACCTGCTACTGATCTACCGCAAGTCCGACGCCGACACCTTG
AAACTGGCGCGACTTGGCTCGCACAGTGAGCTTTTCGACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9751.17 Da
• Isoelectric Point: 5.8684

>AT25563 WP_014003226.1 NC_015850:2119051-2119317 [Acidithiobacillus caldus SM-1]
MSTTDTYVRARIDSRTKERAADALEAMGLSISDAIRLLMLRIAEERRMPFDVKVPNATTRKAIAELEAGKGKRFAGVDDL
MADLHADD

Nucleotide

• Length: 267 bp

>AT25563 NC_015850:2119051-2119317 [Acidithiobacillus caldus SM-1]
ATGAGCACCACCGATACCTATGTCCGCGCCCGCATCGACTCGAGGACCAAGGAGCGCGCTGCTGATGCGCTCGAAGCGAT
GGGGCTGTCCATCTCTGACGCCATCCGCTTGCTGATGCTGCGCATTGCCGAAGAGCGCCGGATGCCATTTGACGTGAAGG
TTCCCAACGCAACCACCCGCAAGGCCATTGCCGAGCTTGAAGCTGGGAAAGGCAAGCGCTTCGCCGGCGTCGATGACCTT
ATGGCGGACTTGCATGCGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1E7YPS8