Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4368815..4369740 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag M5S79_RS21090 Protein ID WP_014640052.1
Coordinates 4368815..4369201 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag M5S79_RS21095 Protein ID WP_024174200.1
Coordinates 4369231..4369740 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS21055 (4364260) 4364260..4364520 - 261 WP_001191669.1 helix-turn-helix transcriptional regulator -
M5S79_RS21060 (4364618) 4364618..4365310 + 693 WP_063079610.1 helix-turn-helix transcriptional regulator -
M5S79_RS21065 (4366013) 4366013..4366375 + 363 WP_000135680.1 protein YfdP -
M5S79_RS21070 (4366441) 4366441..4367265 + 825 WP_000081311.1 DUF2303 family protein -
M5S79_RS21075 (4367454) 4367454..4368236 + 783 WP_047654657.1 hypothetical protein -
M5S79_RS21080 (4368273) 4368273..4368554 + 282 WP_001093916.1 pyocin activator PrtN family protein -
M5S79_RS21085 (4368602) 4368602..4368775 - 174 WP_000390072.1 hypothetical protein -
M5S79_RS21090 (4368815) 4368815..4369201 - 387 WP_014640052.1 hypothetical protein Toxin
M5S79_RS21095 (4369231) 4369231..4369740 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
M5S79_RS21100 (4370057) 4370057..4370161 - 105 Protein_4127 tRNA-dihydrouridine synthase -
M5S79_RS21105 (4370524) 4370524..4371509 - 986 Protein_4128 DUF2713 domain-containing protein -
M5S79_RS21110 (4371827) 4371827..4372342 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
M5S79_RS21115 (4372384) 4372384..4372593 - 210 WP_001030593.1 CsbD family protein -
M5S79_RS21120 (4372709) 4372709..4374034 - 1326 WP_001326646.1 MATE family efflux transporter DinF -
M5S79_RS21125 (4374107) 4374107..4374715 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4325480..4374715 49235
- inside Prophage - espX4 / espX4 4312399..4385046 72647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T255625 WP_014640052.1 NZ_CP103570:c4369201-4368815 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT255625 WP_024174200.1 NZ_CP103570:c4369740-4369231 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References