Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4132917..4133512 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5S79_RS19905 Protein ID WP_000239579.1
Coordinates 4132917..4133267 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5S79_RS19910 Protein ID WP_001223208.1
Coordinates 4133261..4133512 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS19885 (4128193) 4128193..4129215 - 1023 WP_024198507.1 ABC transporter permease -
M5S79_RS19890 (4129229) 4129229..4130731 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
M5S79_RS19895 (4131041) 4131041..4131997 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S79_RS19900 (4132307) 4132307..4132837 + 531 WP_000055072.1 inorganic diphosphatase -
M5S79_RS19905 (4132917) 4132917..4133267 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5S79_RS19910 (4133261) 4133261..4133512 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S79_RS19915 (4133725) 4133725..4134066 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5S79_RS19920 (4134069) 4134069..4137848 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255623 WP_000239579.1 NZ_CP103570:c4133267-4132917 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255623 WP_001223208.1 NZ_CP103570:c4133512-4133261 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References