Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431095..3431713 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S79_RS16540 Protein ID WP_001291435.1
Coordinates 3431495..3431713 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S79_RS16535 Protein ID WP_000344800.1
Coordinates 3431095..3431469 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS16525 (3426184) 3426184..3427377 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S79_RS16530 (3427400) 3427400..3430549 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5S79_RS16535 (3431095) 3431095..3431469 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S79_RS16540 (3431495) 3431495..3431713 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S79_RS16545 (3431885) 3431885..3432436 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5S79_RS16550 (3432552) 3432552..3433022 + 471 WP_000136192.1 YlaC family protein -
M5S79_RS16555 (3433186) 3433186..3434736 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S79_RS16560 (3434778) 3434778..3435131 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S79_RS16570 (3435510) 3435510..3435821 + 312 WP_000409911.1 MGMT family protein -
M5S79_RS16575 (3435852) 3435852..3436424 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255618 WP_001291435.1 NZ_CP103570:3431495-3431713 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255618 WP_000344800.1 NZ_CP103570:3431095-3431469 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References