Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2432691..2433329 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5S79_RS11730 Protein ID WP_001447010.1
Coordinates 2433153..2433329 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S79_RS11725 Protein ID WP_001270286.1
Coordinates 2432691..2433107 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS11705 (2427843) 2427843..2428784 - 942 WP_001251304.1 ABC transporter permease -
M5S79_RS11710 (2428785) 2428785..2429798 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5S79_RS11715 (2429816) 2429816..2430961 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5S79_RS11720 (2431206) 2431206..2432612 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5S79_RS11725 (2432691) 2432691..2433107 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5S79_RS11730 (2433153) 2433153..2433329 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5S79_RS11735 (2433551) 2433551..2433781 + 231 WP_000494244.1 YncJ family protein -
M5S79_RS11740 (2433873) 2433873..2435834 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5S79_RS11745 (2435907) 2435907..2436443 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5S79_RS11750 (2436535) 2436535..2437710 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T255617 WP_001447010.1 NZ_CP103570:c2433329-2433153 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255617 WP_001270286.1 NZ_CP103570:c2433107-2432691 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References