Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1190048..1190640 Replicon chromosome
Accession NC_015850
Organism Acidithiobacillus caldus SM-1

Toxin (Protein)


Gene name hicA Uniprot ID F9ZMS0
Locus tag ATC_RS05900 Protein ID WP_014002702.1
Coordinates 1190048..1190242 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F9ZMS1
Locus tag ATC_RS05905 Protein ID WP_004872948.1
Coordinates 1190239..1190640 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATC_RS05885 1185481..1185873 + 393 WP_014002699.1 hypothetical protein -
ATC_RS05890 1185892..1186263 + 372 WP_014002700.1 VirB3 family type IV secretion system protein -
ATC_RS17325 1186266..1189769 + 3504 WP_014002701.1 conjugal transfer protein TrbE -
ATC_RS05900 1190048..1190242 + 195 WP_014002702.1 type II toxin-antitoxin system HicA family toxin Toxin
ATC_RS05905 1190239..1190640 + 402 WP_004872948.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ATC_RS05910 1191076..1191909 + 834 WP_004872944.1 hypothetical protein -
ATC_RS05915 1192358..1192702 + 345 WP_014002703.1 hypothetical protein -
ATC_RS05920 1192699..1193295 + 597 WP_041636194.1 hypothetical protein -
ATC_RS05925 1193371..1194522 + 1152 WP_041636196.1 hypothetical protein -
ATC_RS16360 1194568..1194693 + 126 Protein_1180 HU family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1182829..1198025 15196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7000.19 Da        Isoelectric Point: 10.8255

>T25561 WP_014002702.1 NC_015850:1190048-1190242 [Acidithiobacillus caldus SM-1]
MNSGDLIKQLLADGWVVRATKGSHHIYIHPNKPGHITVPHPKKDLGVGLVNKILKQAGLKRSES

Download         Length: 195 bp

>T25561 NC_015850:1190048-1190242 [Acidithiobacillus caldus SM-1]
ATGAACAGCGGTGATCTGATCAAGCAGTTGCTGGCCGATGGATGGGTGGTGCGAGCCACGAAAGGCTCGCACCACATTTA
TATTCATCCGAACAAGCCAGGGCATATCACTGTGCCGCATCCCAAGAAGGATCTCGGGGTGGGCTTGGTCAACAAGATCC
TGAAACAGGCTGGCCTGAAACGGAGCGAATCATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14247.10 Da        Isoelectric Point: 4.4575

>AT25561 WP_004872948.1 NC_015850:1190239-1190640 [Acidithiobacillus caldus SM-1]
MNYPIAIEPGDDHHAYGVVVPDLPGCFSAGDTLDEAIANAHEAIALWLETVMDDGGTIPAPSSVESLQKQPEFSGWIWAV
VPVDLAKLSDRVERVNITLPARVLRRIDAAARAAGESRSGYLARCAIMGEPHS

Download         Length: 402 bp

>AT25561 NC_015850:1190239-1190640 [Acidithiobacillus caldus SM-1]
ATGAATTATCCCATTGCCATCGAACCTGGGGATGACCACCACGCTTATGGCGTGGTCGTCCCCGACCTGCCGGGGTGCTT
CTCGGCGGGAGATACGTTGGACGAAGCGATTGCCAACGCCCATGAGGCTATTGCGTTGTGGCTGGAAACCGTGATGGATG
ACGGCGGTACGATTCCTGCGCCATCCTCCGTGGAGTCGCTCCAGAAGCAGCCGGAGTTTTCCGGATGGATCTGGGCTGTG
GTACCGGTGGATCTGGCGAAGTTGTCCGATCGGGTGGAGCGCGTCAACATCACGCTGCCCGCCCGGGTCCTGCGCCGCAT
CGATGCGGCGGCCCGGGCTGCCGGAGAATCCCGCTCAGGCTATCTGGCGCGCTGTGCAATAATGGGCGAACCACATTCGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7YRY8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7YRV7

References