Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1323776..1324401 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag M5S79_RS06425 Protein ID WP_000911329.1
Coordinates 1324003..1324401 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5S79_RS06420 Protein ID WP_000450524.1
Coordinates 1323776..1324003 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS06395 (1319577) 1319577..1320047 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5S79_RS06400 (1320047) 1320047..1320619 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5S79_RS06405 (1320765) 1320765..1321643 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5S79_RS06410 (1321660) 1321660..1322694 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5S79_RS06415 (1322907) 1322907..1323620 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5S79_RS06420 (1323776) 1323776..1324003 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5S79_RS06425 (1324003) 1324003..1324401 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S79_RS06430 (1324548) 1324548..1325411 + 864 WP_001267507.1 neutral zinc metallopeptidase -
M5S79_RS06435 (1325426) 1325426..1327441 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
M5S79_RS06440 (1327515) 1327515..1328213 + 699 WP_000679812.1 esterase -
M5S79_RS06445 (1328323) 1328323..1328523 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T255609 WP_000911329.1 NZ_CP103570:1324003-1324401 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255609 WP_000450524.1 NZ_CP103570:1323776-1324003 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References