Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 865563..866217 Replicon chromosome
Accession NZ_CP103570
Organism Escherichia coli strain 3045

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M5S79_RS04250 Protein ID WP_000244772.1
Coordinates 865810..866217 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5S79_RS04245 Protein ID WP_000354046.1
Coordinates 865563..865829 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S79_RS04220 (860851) 860851..861594 + 744 WP_000951940.1 SDR family oxidoreductase -
M5S79_RS04225 (861651) 861651..863084 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
M5S79_RS04230 (863129) 863129..863440 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M5S79_RS04235 (863604) 863604..864263 + 660 WP_000250274.1 hemolysin III family protein -
M5S79_RS04240 (864340) 864340..865320 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5S79_RS04245 (865563) 865563..865829 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5S79_RS04250 (865810) 865810..866217 + 408 WP_000244772.1 protein YgfX Toxin
M5S79_RS04255 (866257) 866257..866778 - 522 WP_001055874.1 flavodoxin FldB -
M5S79_RS04260 (866890) 866890..867786 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S79_RS04265 (867811) 867811..868521 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S79_RS04270 (868527) 868527..870260 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T255607 WP_000244772.1 NZ_CP103570:865810-866217 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255607 WP_000354046.1 NZ_CP103570:865563-865829 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References