Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4926940..4928621 Replicon chromosome
Accession NZ_CP103567
Organism Klebsiella pneumoniae strain 4680

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M5S58_RS23920 Protein ID WP_002885155.1
Coordinates 4926940..4927857 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5S58_RS23925 Protein ID WP_004177809.1
Coordinates 4927863..4928621 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S58_RS23900 (4922246) 4922246..4923766 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5S58_RS23905 (4923763) 4923763..4924761 + 999 WP_002885172.1 ribose ABC transporter permease -
M5S58_RS23910 (4924792) 4924792..4925733 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M5S58_RS23915 (4925808) 4925808..4926815 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M5S58_RS23920 (4926940) 4926940..4927857 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5S58_RS23925 (4927863) 4927863..4928621 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5S58_RS23930 (4928707) 4928707..4929435 - 729 WP_023159071.1 response regulator transcription factor -
M5S58_RS23935 (4929708) 4929708..4931855 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M5S58_RS23940 (4932085) 4932085..4932771 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T255604 WP_002885155.1 NZ_CP103567:c4927857-4926940 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT255604 WP_004177809.1 NZ_CP103567:c4928621-4927863 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References