Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4765765..4766281 Replicon chromosome
Accession NZ_CP103567
Organism Klebsiella pneumoniae strain 4680

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M5S58_RS23120 Protein ID WP_002886902.1
Coordinates 4765765..4766049 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5S58_RS23125 Protein ID WP_002886901.1
Coordinates 4766039..4766281 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S58_RS23095 (4761182) 4761182..4761445 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
M5S58_RS23100 (4761575) 4761575..4761748 + 174 WP_032410138.1 hypothetical protein -
M5S58_RS23105 (4761751) 4761751..4762494 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
M5S58_RS23110 (4762851) 4762851..4764989 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S58_RS23115 (4765297) 4765297..4765761 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S58_RS23120 (4765765) 4765765..4766049 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S58_RS23125 (4766039) 4766039..4766281 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S58_RS23130 (4766359) 4766359..4768269 - 1911 WP_004152270.1 PRD domain-containing protein -
M5S58_RS23135 (4768292) 4768292..4769446 - 1155 WP_002886900.1 lactonase family protein -
M5S58_RS23140 (4769513) 4769513..4770253 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T255603 WP_002886902.1 NZ_CP103567:c4766049-4765765 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255603 WP_002886901.1 NZ_CP103567:c4766281-4766039 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References