Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2701577..2703165 Replicon chromosome
Accession NZ_CP103567
Organism Klebsiella pneumoniae strain 4680

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag M5S58_RS13230 Protein ID WP_004176197.1
Coordinates 2701577..2702899 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5S58_RS13235 Protein ID WP_032417111.1
Coordinates 2702899..2703165 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S58_RS13215 (2696633) 2696633..2699134 + 2502 WP_016831617.1 fimbria/pilus outer membrane usher protein -
M5S58_RS13220 (2699122) 2699122..2700126 + 1005 WP_004176196.1 fimbrial protein -
M5S58_RS13225 (2700268) 2700268..2701560 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5S58_RS13230 (2701577) 2701577..2702899 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
M5S58_RS13235 (2702899) 2702899..2703165 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5S58_RS13240 (2703430) 2703430..2703756 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5S58_RS13245 (2703753) 2703753..2704253 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5S58_RS13250 (2704231) 2704231..2705610 - 1380 WP_021440115.1 nucleobase:cation symporter-2 family protein -
M5S58_RS13255 (2705956) 2705956..2707110 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5S58_RS13260 (2707091) 2707091..2708014 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T255600 WP_004176197.1 NZ_CP103567:c2702899-2701577 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT255600 WP_032417111.1 NZ_CP103567:c2703165-2702899 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure

References