Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 168432..168979 Replicon chromosome
Accession NC_015850
Organism Acidithiobacillus caldus SM-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ATC_RS00805 Protein ID WP_187288640.1
Coordinates 168432..168758 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ATC_RS00810 Protein ID WP_041635734.1
Coordinates 168755..168979 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATC_RS00780 164052..164723 + 672 WP_014002127.1 type IV secretion system protein -
ATC_RS00785 164735..165907 + 1173 WP_014002128.1 TrbG/VirB9 family P-type conjugative transfer protein -
ATC_RS00790 165904..166824 + 921 WP_014002129.1 TrbG/VirB9 family P-type conjugative transfer protein -
ATC_RS00795 166821..168137 + 1317 WP_014002130.1 conjugal transfer protein TrbI -
ATC_RS00800 168134..168406 + 273 WP_014002131.1 hypothetical protein -
ATC_RS00805 168432..168758 - 327 WP_187288640.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ATC_RS00810 168755..168979 - 225 WP_041635734.1 antitoxin MazE family protein Antitoxin
ATC_RS00815 169174..171198 + 2025 WP_041635735.1 DNA topoisomerase 3 -
ATC_RS16825 171195..171518 + 324 WP_148262184.1 hypothetical protein -
ATC_RS00820 171515..172081 + 567 WP_049784600.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(7-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11586.62 Da        Isoelectric Point: 10.1046

>T25560 WP_187288640.1 NC_015850:c168758-168432 [Acidithiobacillus caldus SM-1]
VMRGDLVTIAMQGDFGKPRPALVIQANQFNEHGTVTLLPITSTLVAAPLMRVTVQPNAENGLQKPSQVMVDKTMTVKRSK
VGPAFGQIDANTLVEVERCLAVFLGVAK

Download         Length: 327 bp

>T25560 NC_015850:c168758-168432 [Acidithiobacillus caldus SM-1]
GTGATGCGGGGCGATCTGGTGACCATCGCCATGCAAGGCGACTTCGGGAAGCCCCGGCCTGCGCTCGTCATACAGGCCAA
CCAGTTCAACGAGCACGGCACCGTTACCCTGCTGCCCATCACCAGCACGCTCGTTGCCGCACCGTTGATGCGCGTCACAG
TTCAGCCGAATGCAGAAAACGGCCTGCAGAAGCCATCGCAAGTGATGGTAGACAAGACCATGACCGTGAAACGCAGCAAG
GTAGGGCCAGCCTTTGGACAAATCGACGCGAACACGCTGGTAGAGGTTGAGCGTTGCCTGGCCGTGTTCTTGGGGGTTGC
CAAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8488.56 Da        Isoelectric Point: 6.0571

>AT25560 WP_041635734.1 NC_015850:c168979-168755 [Acidithiobacillus caldus SM-1]
MATAHVNQRVQKHRDALRKAGLRPVQIWVPDTRRPDFAEECHRQCLLVAQADSADTHMQQLLDEVLADVDGWTE

Download         Length: 225 bp

>AT25560 NC_015850:c168979-168755 [Acidithiobacillus caldus SM-1]
ATGGCCACAGCACACGTGAATCAGCGCGTTCAAAAGCACCGCGATGCACTGCGGAAGGCAGGGCTCCGACCGGTTCAAAT
CTGGGTGCCGGATACGCGCCGCCCAGACTTCGCGGAGGAGTGCCACCGTCAATGCCTGCTTGTGGCTCAGGCAGACAGTG
CCGACACCCACATGCAGCAGCTCCTGGATGAAGTCTTGGCAGACGTGGACGGCTGGACGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References