Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 939087..939744 Replicon chromosome
Accession NZ_CP103567
Organism Klebsiella pneumoniae strain 4680

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5S58_RS04715 Protein ID WP_002916310.1
Coordinates 939334..939744 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S58_RS04710 Protein ID WP_002916312.1
Coordinates 939087..939353 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S58_RS04685 (934243) 934243..935676 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5S58_RS04690 (935795) 935795..936523 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5S58_RS04695 (936573) 936573..936884 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5S58_RS04700 (937048) 937048..937707 + 660 WP_002916317.1 hemolysin III family protein -
M5S58_RS04705 (937858) 937858..938841 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
M5S58_RS04710 (939087) 939087..939353 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S58_RS04715 (939334) 939334..939744 + 411 WP_002916310.1 protein YgfX Toxin
M5S58_RS04720 (939751) 939751..940272 - 522 WP_004144730.1 flavodoxin FldB -
M5S58_RS04725 (940373) 940373..941269 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S58_RS04730 (941292) 941292..942005 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S58_RS04735 (942011) 942011..943744 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255595 WP_002916310.1 NZ_CP103567:939334-939744 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255595 WP_002916312.1 NZ_CP103567:939087-939353 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References