Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4060663..4061329 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MCAN_RS18790 Protein ID WP_015303952.1
Coordinates 4060898..4061329 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MCAN_RS18785 Protein ID WP_041180166.1
Coordinates 4060663..4060911 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS18760 4056474..4057433 + 960 WP_014001808.1 acyl-CoA/acyl-ACP dehydrogenase -
MCAN_RS18765 4057430..4058386 + 957 WP_003419352.1 acyl-CoA/acyl-ACP dehydrogenase -
MCAN_RS18770 4058383..4059549 + 1167 WP_014001809.1 pyridoxal phosphate-dependent aminotransferase -
MCAN_RS18775 4059514..4060365 - 852 WP_014001810.1 arylamine N-acetyltransferase -
MCAN_RS18780 4060350..4060616 - 267 WP_003419367.1 hypothetical protein -
MCAN_RS18785 4060663..4060911 + 249 WP_041180166.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MCAN_RS18790 4060898..4061329 + 432 WP_015303952.1 type II toxin-antitoxin system VapC family toxin Toxin
MCAN_RS18795 4061423..4062685 - 1263 WP_014001811.1 group II intron reverse transcriptase/maturase -
MCAN_RS18800 4063334..4063900 - 567 WP_014001812.1 flavin-dependent monooxygenase reductase subunit HsaB -
MCAN_RS18805 4063903..4064805 - 903 WP_014001813.1 iron-dependent extradiol dioxygenase HsaC -
MCAN_RS18810 4064802..4065677 - 876 WP_014001814.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15746.08 Da        Isoelectric Point: 8.1635

>T25559 WP_015303952.1 NC_015848:4060898-4061329 [Mycobacterium canettii CIPT 140010059]
MLLLDVSVCIFAIREDSCPNHATYRTWLTRLLTGDEPVGISELVLSGVIRLLTNHRVFRQPSTTQQALDSCHALRSAPAA
VALRPGPRHWGIFESLCADVGARANAVPDAYHAALAIENGATWITTDRSFARFPGLRWRLPLS

Download         Length: 432 bp

>T25559 NC_015848:4060898-4061329 [Mycobacterium canettii CIPT 140010059]
ATGCTGCTCCTTGACGTAAGCGTCTGCATATTCGCCATCCGCGAGGACAGCTGCCCCAACCACGCGACATACCGGACGTG
GCTTACCAGACTGCTTACCGGCGACGAACCCGTGGGGATAAGTGAACTCGTGCTATCCGGTGTTATTCGGCTGCTCACCA
ACCATCGGGTATTTCGGCAGCCGAGCACCACGCAGCAGGCGTTGGACTCATGCCATGCGCTGCGGTCCGCACCAGCCGCC
GTCGCGTTACGGCCAGGGCCGCGTCATTGGGGGATCTTCGAATCCCTGTGCGCCGACGTAGGCGCCCGGGCTAATGCGGT
GCCGGACGCCTATCACGCCGCACTGGCAATCGAGAACGGCGCGACGTGGATCACCACCGACCGGTCATTTGCCCGGTTTC
CGGGCCTACGCTGGCGACTCCCCCTGAGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8650.70 Da        Isoelectric Point: 5.0484

>AT25559 WP_041180166.1 NC_015848:4060663-4060911 [Mycobacterium canettii CIPT 140010059]
MRTTVNIDDHLLAEAKILAARTSRSLGAVLEDALRAMLRRSEKGSGNSEFHLPTHGTGGLQAGVDLDDKEALAELIGDNA
AP

Download         Length: 249 bp

>AT25559 NC_015848:4060663-4060911 [Mycobacterium canettii CIPT 140010059]
ATGCGCACCACTGTCAACATCGACGATCACCTGCTCGCCGAGGCGAAGATTCTCGCCGCGAGAACATCGCGATCGCTGGG
AGCAGTACTCGAGGATGCGCTGCGGGCCATGCTGCGGCGGTCCGAGAAGGGATCCGGCAACAGCGAGTTTCACCTGCCGA
CCCACGGCACCGGAGGCTTGCAGGCCGGTGTCGACTTGGACGACAAGGAAGCCCTCGCCGAACTGATCGGCGACAATGCT
GCTCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References