Detailed information of TA system TA025557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3869022..3869692
• Replicon: chromosome
• Accession: NC_015848
• Organism: Mycobacterium canettii CIPT 140010059

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIC0
• Locus tag: MCAN_RS17930
• Protein ID: WP_014001720.1
• Coordinates: 3869022..3869405 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TIC1
• Locus tag: MCAN_RS17935
• Protein ID: WP_014001721.1
• Coordinates: 3869414..3869692 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCAN_RS17915	3864821..3865810	-	990	WP_014001718.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
MCAN_RS17920	3865810..3866862	-	1053	WP_014001719.1	polyprenyl synthetase family protein	-
MCAN_RS17925	3867392..3868621	+	1230	WP_014000877.1	IS256-like element IS1553 family transposase	-
MCAN_RS17930	3869022..3869405	-	384	WP_014001720.1	type II toxin-antitoxin system VapC family toxin	Toxin
MCAN_RS17935	3869414..3869692	-	279	WP_014001721.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MCAN_RS17940	3869863..3871197	+	1335	WP_014000151.1	ISL3-like element IS1557 family transposase	-
MCAN_RS17945	3871249..3872121	-	873	WP_014001722.1	3-hydroxyacyl-thioester dehydratase HtdY	-
MCAN_RS17950	3872195..3872905	+	711	WP_014001723.1	phosphoglycerate mutase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3867392..3871197	3805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-116)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-53)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14057.39 Da
• Isoelectric Point: 10.8376

>T25557 WP_014001720.1 NC_015848:c3869405-3869022 [Mycobacterium canettii CIPT 140010059]
MYLDSSAIVKLAVREPESDALRRYLRTRRPRVSSALARAEVMRALLRQGESARKAGRRVLASLDLLRIDTRVLDLAGALL
PFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAADALGMAVIAPS

Nucleotide

• Length: 384 bp

>T25557 NC_015848:c3869405-3869022 [Mycobacterium canettii CIPT 140010059]
ATGTACCTTGACTCGTCCGCGATCGTCAAGCTGGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGTTACCTTCGCAC
CCGCCGTCCGCGGGTGTCGAGTGCGCTGGCGCGCGCGGAGGTCATGCGGGCTTTGCTGCGGCAGGGTGAGTCAGCGCGGA
AGGCCGGCCGCCGGGTGCTGGCCAGTCTGGATCTGCTTCGCATCGACACCCGCGTCCTCGATCTCGCCGGCGCACTGCTG
CCATTCGAGTTGCGCACGCTCGACGCCATCCACCTGGCGACGGCTCAGCGGCTCGGCGTCGATCTGGGCCGGTTGTGCAC
CTACGACGACCGTATGCGCGACGCCGCAGACGCGCTCGGCATGGCCGTGATCGCCCCGTCGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10121.55 Da
• Isoelectric Point: 4.9170

>AT25557 WP_014001721.1 NC_015848:c3869692-3869414 [Mycobacterium canettii CIPT 140010059]
MASSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPMPEGGPYRRMLASGEIERATVGFDDLPEPIEVEAGVELP
SVTLARLREHER

Nucleotide

• Length: 279 bp

>AT25557 NC_015848:c3869692-3869414 [Mycobacterium canettii CIPT 140010059]
ATGGCGTCGTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAACTTCTCCGCCGCGTCGAGGCCGGCGAGACGAT
CGAGATCACCGATCGTGGTCGGCCCGTGGCACTGCTTTCGCCGATGCCGGAGGGCGGTCCCTACCGGCGGATGTTGGCGA
GTGGTGAGATCGAGCGTGCGACCGTGGGCTTCGATGATCTACCCGAACCGATCGAAGTCGAGGCGGGCGTCGAGCTGCCG
TCGGTGACGCTTGCGCGCCTGCGCGAGCACGAGCGTTGA

Structures

Toxin

• AlphaFold DB: G0TIC0

Antitoxin

• AlphaFold DB: G0TIC1