Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3840484..3841013 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MCAN_RS17810 Protein ID WP_003417760.1
Coordinates 3840756..3841013 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MCAN_RS17805 Protein ID WP_003417757.1
Coordinates 3840484..3840759 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS23205 3837291..3838719 - 1429 Protein_3501 FAD-binding oxidoreductase -
MCAN_RS17790 3838822..3839211 + 390 WP_014001707.1 DUF732 domain-containing protein -
MCAN_RS17795 3839225..3839518 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MCAN_RS17800 3839515..3840360 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MCAN_RS17805 3840484..3840759 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MCAN_RS17810 3840756..3841013 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MCAN_RS17815 3841055..3842245 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MCAN_RS17820 3842362..3842730 + 369 WP_003417765.1 FHA domain-containing protein -
MCAN_RS17825 3842727..3843278 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MCAN_RS17830 3843285..3843866 - 582 WP_003417769.1 ATP/GTP-binding protein -
MCAN_RS17835 3843847..3844215 - 369 WP_003417772.1 DUF742 domain-containing protein -
MCAN_RS17840 3844193..3844585 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T25556 WP_003417760.1 NC_015848:3840756-3841013 [Mycobacterium canettii CIPT 140010059]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T25556 NC_015848:3840756-3841013 [Mycobacterium canettii CIPT 140010059]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT25556 WP_003417757.1 NC_015848:3840484-3840759 [Mycobacterium canettii CIPT 140010059]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT25556 NC_015848:3840484-3840759 [Mycobacterium canettii CIPT 140010059]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References