Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4748434..4749137 Replicon chromosome
Accession NZ_CP103560
Organism Klebsiella pneumoniae strain 5165

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5R31_RS23140 Protein ID WP_071994632.1
Coordinates 4748434..4748775 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5R31_RS23145 Protein ID WP_032434296.1
Coordinates 4748796..4749137 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R31_RS23130 (4744749) 4744749..4745618 + 870 WP_023317468.1 HNH endonuclease -
M5R31_RS23135 (4746209) 4746209..4748242 + 2034 WP_050598589.1 hypothetical protein -
M5R31_RS23140 (4748434) 4748434..4748775 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5R31_RS23145 (4748796) 4748796..4749137 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5R31_RS23150 (4749148) 4749148..4749690 - 543 WP_032434298.1 DNA repair protein RadC -
M5R31_RS23155 (4749703) 4749703..4750143 - 441 WP_032434300.1 antirestriction protein -
M5R31_RS23160 (4750174) 4750174..4750995 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5R31_RS23165 (4751115) 4751115..4751588 - 474 WP_032434303.1 hypothetical protein -
M5R31_RS23170 (4751660) 4751660..4752112 - 453 WP_032410767.1 hypothetical protein -
M5R31_RS23175 (4752148) 4752148..4752864 - 717 WP_032434305.1 WYL domain-containing protein -
M5R31_RS23180 (4753108) 4753108..4753982 - 875 Protein_4541 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4736731..4782404 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T255551 WP_071994632.1 NZ_CP103560:c4748775-4748434 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT255551 WP_032434296.1 NZ_CP103560:c4749137-4748796 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References