Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811058..811715 Replicon chromosome
Accession NZ_CP103560
Organism Klebsiella pneumoniae strain 5165

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5R31_RS04065 Protein ID WP_002916310.1
Coordinates 811305..811715 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5R31_RS04060 Protein ID WP_002916312.1
Coordinates 811058..811324 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R31_RS04035 (806266) 806266..807699 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5R31_RS04040 (807818) 807818..808546 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5R31_RS04045 (808596) 808596..808907 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5R31_RS04050 (809071) 809071..809730 + 660 WP_004174454.1 hemolysin III family protein -
M5R31_RS04055 (809829) 809829..810812 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
M5R31_RS04060 (811058) 811058..811324 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5R31_RS04065 (811305) 811305..811715 + 411 WP_002916310.1 protein YgfX Toxin
M5R31_RS04070 (811722) 811722..812243 - 522 WP_002916308.1 flavodoxin FldB -
M5R31_RS04075 (812344) 812344..813240 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5R31_RS04080 (813263) 813263..813976 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R31_RS04085 (813982) 813982..815715 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255542 WP_002916310.1 NZ_CP103560:811305-811715 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255542 WP_002916312.1 NZ_CP103560:811058-811324 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References