Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4820347..4820844 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M5T18_RS23550 Protein ID WP_001173343.1
Coordinates 4820347..4820520 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag M5T18_RS23555 Protein ID WP_000398619.1
Coordinates 4820548..4820844 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS23540 (4817017) 4817017..4818474 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
M5T18_RS23545 (4818711) 4818711..4820228 + 1518 WP_001550472.1 lysine--tRNA ligase -
M5T18_RS23550 (4820347) 4820347..4820520 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M5T18_RS23555 (4820548) 4820548..4820844 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M5T18_RS23560 (4821073) 4821073..4821345 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M5T18_RS23565 (4821357) 4821357..4821587 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
M5T18_RS23570 (4821767) 4821767..4823398 + 1632 WP_001216477.1 sensor histidine kinase -
M5T18_RS23575 (4823395) 4823395..4824114 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T255538 WP_001173343.1 NZ_CP103559:c4820520-4820347 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT255538 WP_000398619.1 NZ_CP103559:c4820844-4820548 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References