Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4723210..4723805 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag M5T18_RS23045 Protein ID WP_019842229.1
Coordinates 4723210..4723560 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M5T18_RS23050 Protein ID WP_001223213.1
Coordinates 4723554..4723805 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS23025 (4718540) 4718540..4719562 - 1023 WP_001550507.1 ABC transporter permease -
M5T18_RS23030 (4719576) 4719576..4721078 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
M5T18_RS23035 (4721210) 4721210..4722166 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T18_RS23040 (4722476) 4722476..4723006 + 531 WP_000055075.1 inorganic diphosphatase -
M5T18_RS23045 (4723210) 4723210..4723560 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
M5T18_RS23050 (4723554) 4723554..4723805 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T18_RS23055 (4724017) 4724017..4724358 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
M5T18_RS23060 (4724361) 4724361..4728140 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T255537 WP_019842229.1 NZ_CP103559:c4723560-4723210 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT255537 WP_001223213.1 NZ_CP103559:c4723805-4723554 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References