Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3987438..3988056 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T18_RS19540 Protein ID WP_001291435.1
Coordinates 3987838..3988056 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T18_RS19535 Protein ID WP_000344800.1
Coordinates 3987438..3987812 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS19525 (3982527) 3982527..3983720 + 1194 WP_259390505.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T18_RS19530 (3983743) 3983743..3986892 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M5T18_RS19535 (3987438) 3987438..3987812 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T18_RS19540 (3987838) 3987838..3988056 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T18_RS19545 (3988228) 3988228..3988779 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5T18_RS19550 (3988895) 3988895..3989365 + 471 WP_000136192.1 YlaC family protein -
M5T18_RS19555 (3989529) 3989529..3991079 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T18_RS19560 (3991121) 3991121..3991474 - 354 WP_001550741.1 DUF1428 family protein -
M5T18_RS19570 (3991853) 3991853..3992164 + 312 WP_000409911.1 MGMT family protein -
M5T18_RS19575 (3992195) 3992195..3992767 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255533 WP_001291435.1 NZ_CP103559:3987838-3988056 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255533 WP_000344800.1 NZ_CP103559:3987438-3987812 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References