Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3584873..3585578 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5T18_RS17765 Protein ID WP_000539521.1
Coordinates 3584873..3585259 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5T18_RS17770 Protein ID WP_001280945.1
Coordinates 3585249..3585578 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS17745 (3580877) 3580877..3581503 + 627 WP_001295292.1 glutathione S-transferase GstB -
M5T18_RS17750 (3581500) 3581500..3582615 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
M5T18_RS17755 (3582726) 3582726..3583109 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5T18_RS17760 (3583322) 3583322..3584647 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5T18_RS17765 (3584873) 3584873..3585259 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T18_RS17770 (3585249) 3585249..3585578 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5T18_RS17775 (3585648) 3585648..3586976 - 1329 WP_001550887.1 GGDEF domain-containing protein -
M5T18_RS17780 (3586984) 3586984..3589332 - 2349 WP_001550886.1 EAL domain-containing protein -
M5T18_RS17785 (3589510) 3589510..3590421 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T255532 WP_000539521.1 NZ_CP103559:3584873-3585259 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT255532 WP_001280945.1 NZ_CP103559:3585249-3585578 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References