Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2647681..2649269 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name hipA Uniprot ID A0A829LC11
Locus tag M5T18_RS12900 Protein ID WP_001551128.1
Coordinates 2647681..2649003 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T18_RS12905 Protein ID WP_001296726.1
Coordinates 2649003..2649269 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS12880 (2643169) 2643169..2643477 - 309 WP_001221046.1 hypothetical protein -
M5T18_RS12885 (2643616) 2643616..2644515 + 900 WP_001551125.1 LysR family transcriptional regulator -
M5T18_RS12890 (2644882) 2644882..2645914 + 1033 Protein_2517 ISNCY family transposase -
M5T18_RS12895 (2646129) 2646129..2647481 + 1353 WP_001551127.1 SIR2 family protein -
M5T18_RS12900 (2647681) 2647681..2649003 - 1323 WP_001551128.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M5T18_RS12905 (2649003) 2649003..2649269 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2645096..2645914 818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49270.88 Da        Isoelectric Point: 8.2472

>T255524 WP_001551128.1 NZ_CP103559:c2649003-2647681 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT255524 WP_001296726.1 NZ_CP103559:c2649269-2649003 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829LC11

Antitoxin

Source ID Structure

References