Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2543917..2544555 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag M5T18_RS12455 Protein ID WP_000813795.1
Coordinates 2543917..2544093 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T18_RS12460 Protein ID WP_076797675.1
Coordinates 2544139..2544555 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS12435 (2539539) 2539539..2540711 - 1173 WP_001551088.1 BenE family transporter YdcO -
M5T18_RS12440 (2540803) 2540803..2541339 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
M5T18_RS12445 (2541412) 2541412..2543373 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T18_RS12450 (2543465) 2543465..2543695 - 231 WP_023910283.1 YncJ family protein -
M5T18_RS12455 (2543917) 2543917..2544093 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T18_RS12460 (2544139) 2544139..2544555 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T18_RS12465 (2544634) 2544634..2546040 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
M5T18_RS12470 (2546285) 2546285..2547430 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
M5T18_RS12475 (2547448) 2547448..2548461 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
M5T18_RS12480 (2548462) 2548462..2549403 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T255523 WP_000813795.1 NZ_CP103559:2543917-2544093 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT255523 WP_076797675.1 NZ_CP103559:2544139-2544555 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References