Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3236171..3236719 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MCAN_RS15190 Protein ID WP_003414602.1
Coordinates 3236456..3236719 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TFG4
Locus tag MCAN_RS15185 Protein ID WP_014001470.1
Coordinates 3236171..3236452 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS15160 3231794..3232651 - 858 WP_003899513.1 type I methionyl aminopeptidase -
MCAN_RS15165 3232693..3233277 - 585 WP_003414585.1 DUF1707 domain-containing protein -
MCAN_RS15170 3233381..3233629 + 249 WP_003913411.1 antitoxin VapB23 -
MCAN_RS15175 3233626..3234006 + 381 WP_014001468.1 type II toxin-antitoxin system VapC family toxin -
MCAN_RS15180 3234088..3235899 - 1812 WP_014001469.1 penicillin-binding protein -
MCAN_RS15185 3236171..3236452 + 282 WP_014001470.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MCAN_RS15190 3236456..3236719 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MCAN_RS15195 3237093..3237947 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MCAN_RS15200 3238003..3239166 - 1164 WP_014001471.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MCAN_RS15205 3239183..3240397 - 1215 WP_014001472.1 zinc metalloprotease Rip -
MCAN_RS15210 3240405..3241646 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T25552 WP_003414602.1 NC_015848:3236456-3236719 [Mycobacterium canettii CIPT 140010059]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T25552 NC_015848:3236456-3236719 [Mycobacterium canettii CIPT 140010059]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACGACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10210.47 Da        Isoelectric Point: 4.4805

>AT25552 WP_014001470.1 NC_015848:3236171-3236452 [Mycobacterium canettii CIPT 140010059]
MRILPISKIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT25552 NC_015848:3236171-3236452 [Mycobacterium canettii CIPT 140010059]
ATGCGGATACTGCCGATTTCGAAGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB G0TFG4

References