Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 925949..926603 Replicon chromosome
Accession NZ_CP103559
Organism Escherichia coli strain 3059

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M5T18_RS04495 Protein ID WP_000244781.1
Coordinates 926196..926603 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T18_RS04490 Protein ID WP_000354046.1
Coordinates 925949..926215 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T18_RS04470 (922037) 922037..923470 - 1434 WP_001305827.1 6-phospho-beta-glucosidase BglA -
M5T18_RS04475 (923515) 923515..923826 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
M5T18_RS04480 (923990) 923990..924649 + 660 WP_000250274.1 hemolysin III family protein -
M5T18_RS04485 (924726) 924726..925706 - 981 WP_135132679.1 tRNA-modifying protein YgfZ -
M5T18_RS04490 (925949) 925949..926215 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T18_RS04495 (926196) 926196..926603 + 408 WP_000244781.1 protein YgfX Toxin
M5T18_RS04500 (926643) 926643..927164 - 522 WP_001055888.1 flavodoxin FldB -
M5T18_RS04505 (927276) 927276..928172 + 897 WP_000806628.1 site-specific tyrosine recombinase XerD -
M5T18_RS04510 (928197) 928197..928907 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T18_RS04515 (928913) 928913..930646 + 1734 WP_000813175.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T255512 WP_000244781.1 NZ_CP103559:926196-926603 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255512 WP_000354046.1 NZ_CP103559:925949-926215 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References