Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4594533..4595128 Replicon chromosome
Accession NZ_CP103557
Organism Escherichia coli O25b:H4-ST131 strain 4993

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T49_RS23015 Protein ID WP_000239579.1
Coordinates 4594533..4594883 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T49_RS23020 Protein ID WP_001223208.1
Coordinates 4594877..4595128 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T49_RS22995 (4589979) 4589979..4591001 - 1023 WP_001296689.1 ABC transporter permease -
M5T49_RS23000 (4591015) 4591015..4592517 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
M5T49_RS23005 (4592657) 4592657..4593613 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T49_RS23010 (4593923) 4593923..4594453 + 531 WP_000055075.1 inorganic diphosphatase -
M5T49_RS23015 (4594533) 4594533..4594883 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T49_RS23020 (4594877) 4594877..4595128 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T49_RS23025 (4595340) 4595340..4595681 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T49_RS23030 (4595684) 4595684..4599463 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T255501 WP_000239579.1 NZ_CP103557:c4594883-4594533 [Escherichia coli O25b:H4-ST131]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255501 WP_001223208.1 NZ_CP103557:c4595128-4594877 [Escherichia coli O25b:H4-ST131]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References