Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3171712..3172487 | Replicon | chromosome |
| Accession | NC_015848 | ||
| Organism | Mycobacterium canettii CIPT 140010059 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | MCAN_RS21760 | Protein ID | WP_015288375.1 |
| Coordinates | 3171984..3172487 (+) | Length | 168 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | G0TFA8 |
| Locus tag | MCAN_RS14850 | Protein ID | WP_014001432.1 |
| Coordinates | 3171712..3171987 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCAN_RS14815 | 3166849..3167175 | - | 327 | WP_014001427.1 | hypothetical protein | - |
| MCAN_RS14820 | 3167334..3167909 | + | 576 | WP_014001428.1 | DUF3558 domain-containing protein | - |
| MCAN_RS14825 | 3167928..3169613 | + | 1686 | WP_014001429.1 | CocE/NonD family hydrolase | - |
| MCAN_RS14830 | 3169632..3169988 | - | 357 | WP_014001430.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | - |
| MCAN_RS14835 | 3169972..3170202 | - | 231 | WP_015288373.1 | ribbon-helix-helix domain-containing protein | - |
| MCAN_RS14840 | 3170245..3171288 | - | 1044 | WP_014001431.1 | DUF2293 domain-containing protein | - |
| MCAN_RS22505 | 3171302..3171457 | - | 156 | WP_145974198.1 | DUF1802 family protein | - |
| MCAN_RS14850 | 3171712..3171987 | + | 276 | WP_014001432.1 | DUF1778 domain-containing protein | Antitoxin |
| MCAN_RS21760 | 3171984..3172487 | + | 504 | WP_015288375.1 | GNAT family N-acetyltransferase | Toxin |
| MCAN_RS14860 | 3172556..3172959 | + | 404 | Protein_2925 | hypothetical protein | - |
| MCAN_RS14865 | 3172956..3173147 | + | 192 | WP_014001435.1 | hypothetical protein | - |
| MCAN_RS14870 | 3173411..3173650 | - | 240 | WP_015288376.1 | hypothetical protein | - |
| MCAN_RS14875 | 3173666..3173926 | - | 261 | WP_015288377.1 | hypothetical protein | - |
| MCAN_RS22510 | 3174196..3174464 | - | 269 | Protein_2929 | hypothetical protein | - |
| MCAN_RS21770 | 3174520..3174861 | + | 342 | WP_080602971.1 | hypothetical protein | - |
| MCAN_RS14890 | 3175190..3175552 | + | 363 | WP_015288379.1 | hypothetical protein | - |
| MCAN_RS14895 | 3175708..3177441 | + | 1734 | WP_015288380.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 168 a.a. Molecular weight: 18196.93 Da Isoelectric Point: 10.0754
>T25550 WP_015288375.1 NC_015848:3171984-3172487 [Mycobacterium canettii CIPT 140010059]
MSTPALGPVELLDPDRHDTARFSSGVEVLDHWLRRVAPVAAAAGTAATWVLCRGRRVVGFYALAMGSIERIRVPSRPGRG
QPDPIPVLVLARLALDRQEQGTGLGGDLLLDALIRSVAGARQYGARALVVDALDDRAAEFYRHHGFLPLDGRRLYRRISD
IERALGV
MSTPALGPVELLDPDRHDTARFSSGVEVLDHWLRRVAPVAAAAGTAATWVLCRGRRVVGFYALAMGSIERIRVPSRPGRG
QPDPIPVLVLARLALDRQEQGTGLGGDLLLDALIRSVAGARQYGARALVVDALDDRAAEFYRHHGFLPLDGRRLYRRISD
IERALGV
Download Length: 504 bp
>T25550 NC_015848:3171984-3172487 [Mycobacterium canettii CIPT 140010059]
TTGAGCACCCCCGCGCTCGGCCCCGTCGAGCTGTTGGACCCGGACCGGCACGACACGGCGCGCTTCTCCAGCGGTGTTGA
GGTTCTCGACCACTGGCTGCGTCGAGTCGCGCCCGTCGCGGCTGCGGCCGGCACGGCCGCTACGTGGGTGCTCTGTCGAG
GCCGGCGGGTAGTTGGGTTCTACGCGCTCGCCATGGGGAGCATCGAGCGGATCCGGGTGCCATCGCGGCCGGGCCGGGGC
CAACCCGACCCGATCCCGGTGCTCGTGCTCGCTCGCCTGGCACTCGACCGGCAGGAGCAGGGCACCGGTCTCGGTGGCGA
TCTTCTCCTCGATGCCCTCATCCGATCCGTGGCCGGCGCCCGGCAGTATGGCGCCCGCGCCCTGGTCGTAGACGCCCTCG
ACGACCGCGCCGCCGAGTTCTACCGTCACCACGGCTTCTTGCCCCTCGACGGTCGACGCCTCTACCGGCGGATCAGCGAC
ATCGAGCGGGCGCTGGGAGTATGA
TTGAGCACCCCCGCGCTCGGCCCCGTCGAGCTGTTGGACCCGGACCGGCACGACACGGCGCGCTTCTCCAGCGGTGTTGA
GGTTCTCGACCACTGGCTGCGTCGAGTCGCGCCCGTCGCGGCTGCGGCCGGCACGGCCGCTACGTGGGTGCTCTGTCGAG
GCCGGCGGGTAGTTGGGTTCTACGCGCTCGCCATGGGGAGCATCGAGCGGATCCGGGTGCCATCGCGGCCGGGCCGGGGC
CAACCCGACCCGATCCCGGTGCTCGTGCTCGCTCGCCTGGCACTCGACCGGCAGGAGCAGGGCACCGGTCTCGGTGGCGA
TCTTCTCCTCGATGCCCTCATCCGATCCGTGGCCGGCGCCCGGCAGTATGGCGCCCGCGCCCTGGTCGTAGACGCCCTCG
ACGACCGCGCCGCCGAGTTCTACCGTCACCACGGCTTCTTGCCCCTCGACGGTCGACGCCTCTACCGGCGGATCAGCGAC
ATCGAGCGGGCGCTGGGAGTATGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10042.42 Da Isoelectric Point: 9.1613
>AT25550 WP_014001432.1 NC_015848:3171712-3171987 [Mycobacterium canettii CIPT 140010059]
MPETLTGRLNFRLSPEQEQALRRAAALTGQSLSGFVLSAAVDHAHDLLARANRIELSEAAFRRFVAALDEPDEAAPELVR
LARRKSRIPAH
MPETLTGRLNFRLSPEQEQALRRAAALTGQSLSGFVLSAAVDHAHDLLARANRIELSEAAFRRFVAALDEPDEAAPELVR
LARRKSRIPAH
Download Length: 276 bp
>AT25550 NC_015848:3171712-3171987 [Mycobacterium canettii CIPT 140010059]
ATGCCCGAGACTCTGACTGGTCGCCTCAACTTCCGCCTGTCTCCTGAACAGGAGCAGGCCCTTCGCCGCGCCGCCGCGCT
CACCGGCCAGAGCCTGTCGGGGTTCGTATTGTCCGCCGCGGTCGACCACGCCCACGATCTCTTGGCCCGGGCCAACCGGA
TCGAGCTGTCCGAGGCCGCTTTCCGCCGCTTCGTCGCCGCGCTCGACGAGCCCGACGAGGCGGCTCCCGAATTGGTGCGC
CTCGCCAGACGGAAGAGCCGCATTCCCGCCCATTGA
ATGCCCGAGACTCTGACTGGTCGCCTCAACTTCCGCCTGTCTCCTGAACAGGAGCAGGCCCTTCGCCGCGCCGCCGCGCT
CACCGGCCAGAGCCTGTCGGGGTTCGTATTGTCCGCCGCGGTCGACCACGCCCACGATCTCTTGGCCCGGGCCAACCGGA
TCGAGCTGTCCGAGGCCGCTTTCCGCCGCTTCGTCGCCGCGCTCGACGAGCCCGACGAGGCGGCTCCCGAATTGGTGCGC
CTCGCCAGACGGAAGAGCCGCATTCCCGCCCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|