Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 984598..985252 Replicon chromosome
Accession NZ_CP103557
Organism Escherichia coli O25b:H4-ST131 strain 4993

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5T49_RS04870 Protein ID WP_000244765.1
Coordinates 984845..985252 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5T49_RS04865 Protein ID WP_000354050.1
Coordinates 984598..984864 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T49_RS04845 (980686) 980686..982119 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5T49_RS04850 (982164) 982164..982475 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5T49_RS04855 (982639) 982639..983298 + 660 WP_000250275.1 hemolysin III family protein -
M5T49_RS04860 (983375) 983375..984355 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
M5T49_RS04865 (984598) 984598..984864 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5T49_RS04870 (984845) 984845..985252 + 408 WP_000244765.1 protein YgfX Toxin
M5T49_RS04875 (985292) 985292..985813 - 522 WP_001055874.1 flavodoxin FldB -
M5T49_RS04880 (985925) 985925..986821 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T49_RS04885 (986846) 986846..987556 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T49_RS04890 (987562) 987562..989295 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T255487 WP_000244765.1 NZ_CP103557:984845-985252 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT255487 WP_000354050.1 NZ_CP103557:984598-984864 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References