Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 690246..691081 Replicon chromosome
Accession NZ_CP103557
Organism Escherichia coli O25b:H4-ST131 strain 4993

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J5ZPW7
Locus tag M5T49_RS03385 Protein ID WP_000854722.1
Coordinates 690704..691081 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K4A940
Locus tag M5T49_RS03380 Protein ID WP_001285576.1
Coordinates 690246..690614 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T49_RS03360 (687971) 687971..688789 + 819 WP_021520251.1 DUF932 domain-containing protein -
M5T49_RS03365 (688881) 688881..689366 + 486 WP_000206656.1 antirestriction protein -
M5T49_RS03370 (689382) 689382..689858 + 477 WP_001360063.1 RadC family protein -
M5T49_RS03375 (689945) 689945..690166 + 222 WP_000692176.1 DUF987 domain-containing protein -
M5T49_RS03380 (690246) 690246..690614 + 369 WP_001285576.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T49_RS03385 (690704) 690704..691081 + 378 WP_000854722.1 TA system toxin CbtA family protein Toxin
M5T49_RS03390 (691078) 691078..691566 + 489 WP_000761669.1 DUF5983 family protein -
M5T49_RS03395 (691586) 691586..691783 + 198 WP_000445281.1 DUF957 domain-containing protein -
M5T49_RS03400 (691868) 691868..692713 + 846 WP_001280427.1 DUF4942 domain-containing protein -
M5T49_RS03410 (693013) 693013..693519 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
M5T49_RS03415 (693597) 693597..695438 - 1842 WP_000437380.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2904

>T255485 WP_000854722.1 NZ_CP103557:690704-691081 [Escherichia coli O25b:H4-ST131]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13599.36 Da        Isoelectric Point: 6.3159

>AT255485 WP_001285576.1 NZ_CP103557:690246-690614 [Escherichia coli O25b:H4-ST131]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5ZPW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K4A940

References