Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5257032..5257804 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M5R35_RS24780 Protein ID WP_196588755.1
Coordinates 5257032..5257421 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag M5R35_RS24785 Protein ID WP_196588787.1
Coordinates 5257478..5257804 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS24750 (M5R35_24750) 5252084..5252878 + 795 WP_038422857.1 DNA/RNA non-specific endonuclease -
M5R35_RS24755 (M5R35_24755) 5253168..5253491 + 324 WP_014227722.1 endoribonuclease SymE -
M5R35_RS24760 (M5R35_24760) 5253638..5254072 + 435 WP_004098173.1 VOC family protein -
M5R35_RS24765 (M5R35_24765) 5254238..5254981 + 744 WP_014227721.1 hypothetical protein -
M5R35_RS24770 (M5R35_24770) 5255165..5255956 - 792 WP_196588753.1 helix-turn-helix transcriptional regulator -
M5R35_RS24775 (M5R35_24775) 5256100..5256945 - 846 WP_196588754.1 DUF4942 domain-containing protein -
M5R35_RS24780 (M5R35_24780) 5257032..5257421 - 390 WP_196588755.1 TA system toxin CbtA family protein Toxin
M5R35_RS24785 (M5R35_24785) 5257478..5257804 - 327 WP_196588787.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5R35_RS24790 (M5R35_24790) 5257862..5258083 - 222 WP_196588756.1 DUF987 domain-containing protein -
M5R35_RS24795 (M5R35_24795) 5258097..5258576 - 480 WP_196588757.1 DNA repair protein RadC -
M5R35_RS24800 (M5R35_24800) 5258588..5259037 - 450 WP_196588758.1 antirestriction protein -
M5R35_RS24805 (M5R35_24805) 5259070..5259891 - 822 WP_196588759.1 DUF932 domain-containing protein -
M5R35_RS24810 (M5R35_24810) 5260224..5261174 - 951 WP_196588760.1 hypothetical protein -
M5R35_RS24815 (M5R35_24815) 5261769..5262410 + 642 WP_196588761.1 inovirus Gp2 family protein -
M5R35_RS24820 (M5R35_24820) 5262518..5262733 + 216 WP_099973487.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5253638..5274510 20872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14481.58 Da        Isoelectric Point: 9.5233

>T255480 WP_196588755.1 NZ_CP103554:c5257421-5257032 [Klebsiella michiganensis]
MQTKSSPLARAASSRLSPVYIWQTLLTCLLEHHYGLTLSDTPFIDEQVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITPIDILRARKATGLMNRGTYKEVTAITRAQHPQASTSGKR

Download         Length: 390 bp

>T255480 NZ_CP103554:c5257421-5257032 [Klebsiella michiganensis]
ATGCAAACCAAATCATCTCCCCTCGCGCGGGCGGCATCGTCACGTCTGTCTCCCGTGTATATCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTCACGCTTAGCGATACGCCGTTCATTGATGAACAGGTGATTCAGCAACATATCG
AGGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTTGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAGTCTCCGTTTATCACGCCCATTGATATCCTCCGGGCCAGAAAGGCTACGGGTCTGATGAACCGTGG
CACGTATAAAGAGGTGACGGCTATTACCAGAGCACAACATCCGCAGGCCAGCACTTCAGGCAAGCGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12073.78 Da        Isoelectric Point: 7.3495

>AT255480 WP_196588787.1 NZ_CP103554:c5257804-5257478 [Klebsiella michiganensis]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANVSGQFCDAYLRHLDQAFPVLMKQLELMLTSGELNPRHQHGVTLYA
KGLTCEADNLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp

>AT255480 NZ_CP103554:c5257804-5257478 [Klebsiella michiganensis]
ATCAGCGAACCCTGGTGGGGGCTCAGACGCAGTGTCTCCCCGTGTTTTGGGGCCCGCCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGGGCGAATGTTAGCGGACAGTTCTGTGATGCATATTTGCGCCATCTTGATCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACGGCGTCACACTGTATGCA
AAAGGTCTGACGTGTGAGGCTGATAACCTTGGTTCGCATGGCTACGTTTATATCGCGATTTATCCCACCCCTGTCGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References