255479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 5200859..5201435 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag M5R35_RS24520 Protein ID WP_071881753.1
Coordinates 5201148..5201435 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0H3H591
Locus tag M5R35_RS24515 Protein ID WP_014227757.1
Coordinates 5200859..5201161 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS24500 (M5R35_24500) 5197697..5198032 + 336 WP_014227760.1 endoribonuclease SymE -
M5R35_RS24505 (M5R35_24505) 5198486..5199397 + 912 WP_014227759.1 acetamidase/formamidase family protein -
M5R35_RS24510 (M5R35_24510) 5199394..5200737 + 1344 WP_014227758.1 APC family permease -
M5R35_RS24515 (M5R35_24515) 5200859..5201161 - 303 WP_014227757.1 BrnA antitoxin family protein Antitoxin
M5R35_RS24520 (M5R35_24520) 5201148..5201435 - 288 WP_071881753.1 BrnT family toxin Toxin
M5R35_RS24525 (M5R35_24525) 5201686..5202129 - 444 WP_014227755.1 FosA family fosfomycin resistance glutathione transferase -
M5R35_RS24530 (M5R35_24530) 5202123..5203031 - 909 WP_014227754.1 LysR family transcriptional regulator -
M5R35_RS24535 (M5R35_24535) 5203119..5203901 + 783 WP_014227753.1 NAD(P)H-dependent oxidoreductase -
M5R35_RS24540 (M5R35_24540) 5204049..5204633 + 585 WP_004098242.1 TetR/AcrR family transcriptional regulator -
M5R35_RS24545 (M5R35_24545) 5204779..5205579 + 801 WP_014227752.1 winged helix-turn-helix domain-containing protein -
M5R35_RS24550 (M5R35_24550) 5205576..5206094 + 519 WP_004098240.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11239.69 Da        Isoelectric Point: 8.5899

>T255479 WP_071881753.1 NZ_CP103554:c5201435-5201148 [Klebsiella michiganensis]
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTLGLVHGVIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11607.18 Da        Isoelectric Point: 9.4429

>AT255479 WP_014227757.1 NZ_CP103554:c5201161-5200859 [Klebsiella michiganensis]
MNMVKHKRDNPDTLTAKRDDELKALANKTDDEIDYSDIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H591

References