255478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4744121..4744940 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag M5R35_RS22455 Protein ID WP_004110819.1
Coordinates 4744683..4744940 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A0H3H6E6
Locus tag M5R35_RS22450 Protein ID WP_014228055.1
Coordinates 4744121..4744672 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS22430 (M5R35_22430) 4740345..4741253 - 909 WP_014228058.1 transcriptional regulator GcvA -
M5R35_RS22435 (M5R35_22435) 4741373..4742260 + 888 WP_038423347.1 DMT family transporter -
M5R35_RS22440 (M5R35_22440) 4742475..4743221 - 747 WP_014228056.1 class I SAM-dependent methyltransferase -
M5R35_RS22445 (M5R35_22445) 4743648..4744007 - 360 Protein_4416 class I SAM-dependent methyltransferase -
M5R35_RS22450 (M5R35_22450) 4744121..4744672 - 552 WP_014228055.1 N-acetyltransferase Antitoxin
M5R35_RS22455 (M5R35_22455) 4744683..4744940 - 258 WP_004110819.1 YjhX family toxin Toxin
M5R35_RS22460 (M5R35_22460) 4745616..4746800 + 1185 WP_014228054.1 mannonate dehydratase -
M5R35_RS22465 (M5R35_22465) 4746874..4748349 + 1476 WP_014228053.1 fructuronate reductase -
M5R35_RS22470 (M5R35_22470) 4748488..4749264 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T255478 WP_004110819.1 NZ_CP103554:c4744940-4744683 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20048.90 Da        Isoelectric Point: 6.3992

>AT255478 WP_014228055.1 NZ_CP103554:c4744672-4744121 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRYGFEPCAGDKGYPAPYPIPAAHKGCWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H6E6

References