Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4704014..4704759 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag M5R35_RS22275 Protein ID WP_071790696.1
Coordinates 4704391..4704759 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag M5R35_RS22270 Protein ID WP_148842345.1
Coordinates 4704014..4704370 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS22235 (M5R35_22235) 4700051..4700767 + 717 WP_148842339.1 WYL domain-containing protein -
M5R35_RS22240 (M5R35_22240) 4700803..4701255 + 453 WP_049082528.1 hypothetical protein -
M5R35_RS22245 (M5R35_22245) 4701327..4701800 + 474 WP_148842340.1 hypothetical protein -
M5R35_RS22250 (M5R35_22250) 4701920..4702759 + 840 WP_148842341.1 DUF932 domain-containing protein -
M5R35_RS22255 (M5R35_22255) 4702772..4703215 + 444 WP_148842342.1 antirestriction protein -
M5R35_RS22260 (M5R35_22260) 4703228..4703770 + 543 WP_196588657.1 DNA repair protein RadC -
M5R35_RS22265 (M5R35_22265) 4703767..4703988 + 222 WP_148842344.1 DUF987 family protein -
M5R35_RS22270 (M5R35_22270) 4704014..4704370 + 357 WP_148842345.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5R35_RS22275 (M5R35_22275) 4704391..4704759 + 369 WP_071790696.1 TA system toxin CbtA family protein Toxin
M5R35_RS22280 (M5R35_22280) 4705491..4708004 + 2514 WP_014228086.1 type VI secretion system tip protein VgrG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4679714..4717426 37712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13683.95 Da        Isoelectric Point: 8.7174

>T255477 WP_071790696.1 NZ_CP103554:4704391-4704759 [Klebsiella michiganensis]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSPVQAPYLTTTDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13126.69 Da        Isoelectric Point: 5.4432

>AT255477 WP_148842345.1 NZ_CP103554:4704014-4704370 [Klebsiella michiganensis]
MNNHSESGDKPENPACQQWGLKSTITPCFGARLVQEGNRVHFLADRAGFNGDFSDDDALHLDQVFPLILKQLELMLTSGE
LSSRHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References