255470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1309357..1310024 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag M5R35_RS06330 Protein ID WP_196588618.1
Coordinates 1309357..1309686 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag M5R35_RS06335 Protein ID WP_165716179.1
Coordinates 1309707..1310024 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS06310 (M5R35_06310) 1305808..1305897 - 90 Protein_1237 MurR/RpiR family transcriptional regulator -
M5R35_RS06315 (M5R35_06315) 1306489..1306575 + 87 Protein_1238 type VI secretion system contractile sheath small subunit -
M5R35_RS06320 (M5R35_06320) 1306693..1308267 + 1575 WP_014226460.1 type VI secretion system protein TssA -
M5R35_RS06325 (M5R35_06325) 1308369..1308848 + 480 WP_014226459.1 hypothetical protein -
M5R35_RS06330 (M5R35_06330) 1309357..1309686 - 330 WP_196588618.1 TA system toxin CbtA family protein Toxin
M5R35_RS06335 (M5R35_06335) 1309707..1310024 - 318 WP_165716179.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5R35_RS06340 (M5R35_06340) 1310043..1310264 - 222 WP_165716178.1 DUF987 domain-containing protein -
M5R35_RS06345 (M5R35_06345) 1310273..1310755 - 483 WP_165716177.1 DNA repair protein RadC -
M5R35_RS06350 (M5R35_06350) 1310764..1311222 - 459 WP_196588619.1 antirestriction protein -
M5R35_RS06355 (M5R35_06355) 1311308..1311544 - 237 Protein_1246 DUF905 domain-containing protein -
M5R35_RS06360 (M5R35_06360) 1311622..1312032 - 411 WP_064791165.1 hypothetical protein -
M5R35_RS06365 (M5R35_06365) 1312099..1312536 - 438 WP_023321463.1 hypothetical protein -
M5R35_RS06370 (M5R35_06370) 1312578..1313114 - 537 WP_165716174.1 DUF4339 domain-containing protein -
M5R35_RS06375 (M5R35_06375) 1313140..1313850 - 711 WP_047174770.1 DeoR family transcriptional regulator -
M5R35_RS06380 (M5R35_06380) 1314059..1314883 - 825 WP_127785964.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12209.18 Da        Isoelectric Point: 7.8584

>T255470 WP_196588618.1 NZ_CP103554:c1309686-1309357 [Klebsiella michiganensis]
MKNLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRKGF
SWQEQTPCLSVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11913.53 Da        Isoelectric Point: 7.3232

>AT255470 WP_165716179.1 NZ_CP103554:c1310024-1309707 [Klebsiella michiganensis]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRKLDETFPHFISRMESMLTTGEMNPRHAHCVILYH
NGFTCEADTLGSCGYVYIAVYPTKR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References