Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 864172..864829 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag M5R35_RS04195 Protein ID WP_004854060.1
Coordinates 864419..864829 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag M5R35_RS04190 Protein ID WP_004124953.1
Coordinates 864172..864438 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS04175 (M5R35_04175) 859406..859831 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
M5R35_RS04180 (M5R35_04180) 859952..862750 - 2799 WP_014226794.1 transcriptional regulator DagR -
M5R35_RS04185 (M5R35_04185) 862944..863927 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
M5R35_RS04190 (M5R35_04190) 864172..864438 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
M5R35_RS04195 (M5R35_04195) 864419..864829 + 411 WP_004854060.1 protein YgfX Toxin
M5R35_RS04200 (M5R35_04200) 864838..865359 - 522 WP_014226792.1 flavodoxin FldB -
M5R35_RS04205 (M5R35_04205) 865481..866377 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
M5R35_RS04210 (M5R35_04210) 866400..867113 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R35_RS04215 (M5R35_04215) 867119..868852 + 1734 WP_014226791.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T255469 WP_004854060.1 NZ_CP103554:864419-864829 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT255469 WP_004124953.1 NZ_CP103554:864172-864438 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References