255468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 57248..57795 Replicon chromosome
Accession NZ_CP103554
Organism Klebsiella michiganensis strain 5088

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag M5R35_RS00290 Protein ID WP_014227299.1
Coordinates 57248..57556 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag M5R35_RS00295 Protein ID WP_014227298.1
Coordinates 57559..57795 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R35_RS00260 (M5R35_00260) 52883..53194 - 312 WP_014227304.1 PTS sugar transporter subunit IIB -
M5R35_RS00265 (M5R35_00265) 53489..54430 + 942 WP_014227303.1 LacI family DNA-binding transcriptional regulator -
M5R35_RS00270 (M5R35_00270) 54454..54747 - 294 WP_014227302.1 YicS family protein -
M5R35_RS00275 (M5R35_00275) 54957..55934 + 978 WP_032695133.1 Rpn family recombination-promoting nuclease/putative transposase -
M5R35_RS00280 (M5R35_00280) 56009..56191 + 183 WP_014839831.1 hypothetical protein -
M5R35_RS00285 (M5R35_00285) 56195..57097 - 903 WP_014227300.1 EamA family transporter -
M5R35_RS00290 (M5R35_00290) 57248..57556 - 309 WP_014227299.1 CcdB family protein Toxin
M5R35_RS00295 (M5R35_00295) 57559..57795 - 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M5R35_RS00300 (M5R35_00300) 57901..59334 - 1434 WP_014227297.1 PTS N-acetylmuramic acid transporter subunit IIBC -
M5R35_RS00305 (M5R35_00305) 59359..60261 - 903 WP_009654080.1 N-acetylmuramic acid 6-phosphate etherase -
M5R35_RS00310 (M5R35_00310) 60422..61588 - 1167 WP_014227296.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T255468 WP_014227299.1 NZ_CP103554:c57556-57248 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT255468 WP_014227298.1 NZ_CP103554:c57795-57559 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H5T3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References