Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5809..6334 Replicon plasmid pMB8806_2
Accession NZ_CP103552
Organism Klebsiella pneumoniae strain 2791

Toxin (Protein)


Gene name ccdB Uniprot ID W8UQV6
Locus tag M5T34_RS26790 Protein ID WP_001568026.1
Coordinates 5809..6114 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag M5T34_RS26795 Protein ID WP_001568025.1
Coordinates 6116..6334 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T34_RS26760 (M5T34_26760) 1501..2127 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
M5T34_RS26765 (M5T34_26765) 2124..2426 + 303 WP_004197636.1 hypothetical protein -
M5T34_RS26770 (M5T34_26770) 2890..3684 - 795 WP_004197635.1 site-specific integrase -
M5T34_RS26775 (M5T34_26775) 3882..4898 - 1017 WP_020315256.1 hypothetical protein -
M5T34_RS26780 (M5T34_26780) 4895..5218 - 324 WP_022644730.1 hypothetical protein -
M5T34_RS26785 (M5T34_26785) 5245..5640 - 396 WP_017899885.1 hypothetical protein -
M5T34_RS26790 (M5T34_26790) 5809..6114 - 306 WP_001568026.1 type II toxin-antitoxin system toxin CcdB Toxin
M5T34_RS26795 (M5T34_26795) 6116..6334 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
M5T34_RS26800 (M5T34_26800) 7167..7619 + 453 WP_004201034.1 hypothetical protein -
M5T34_RS26805 (M5T34_26805) 8136..8756 + 621 WP_023292072.1 DNA-binding protein -
M5T34_RS26810 (M5T34_26810) 8753..9817 + 1065 WP_023292073.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IIa / dfrA14 - 1..55976 55976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11645.32 Da        Isoelectric Point: 5.6919

>T255465 WP_001568026.1 NZ_CP103552:c6114-5809 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT255465 WP_001568025.1 NZ_CP103552:c6334-6116 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EZN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References