Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4963147..4964828 Replicon chromosome
Accession NZ_CP103550
Organism Klebsiella pneumoniae strain 2791

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M5T34_RS24225 Protein ID WP_002885155.1
Coordinates 4963147..4964064 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5T34_RS24230 Protein ID WP_004177809.1
Coordinates 4964070..4964828 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T34_RS24205 (4958453) 4958453..4959973 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5T34_RS24210 (4959970) 4959970..4960968 + 999 WP_002885172.1 ribose ABC transporter permease -
M5T34_RS24215 (4960999) 4960999..4961940 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M5T34_RS24220 (4962015) 4962015..4963022 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M5T34_RS24225 (4963147) 4963147..4964064 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5T34_RS24230 (4964070) 4964070..4964828 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5T34_RS24235 (4964914) 4964914..4965642 - 729 WP_004177810.1 response regulator transcription factor -
M5T34_RS24240 (4965915) 4965915..4968062 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
M5T34_RS24245 (4968292) 4968292..4968978 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T255462 WP_002885155.1 NZ_CP103550:c4964064-4963147 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT255462 WP_004177809.1 NZ_CP103550:c4964828-4964070 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References