Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4913806..4914509 Replicon chromosome
Accession NZ_CP103550
Organism Klebsiella pneumoniae strain 2791

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5T34_RS24000 Protein ID WP_071994632.1
Coordinates 4914168..4914509 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5T34_RS23995 Protein ID WP_032434296.1
Coordinates 4913806..4914147 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T34_RS23960 (4908961) 4908961..4909835 + 875 Protein_4694 GTPase family protein -
M5T34_RS23965 (4910079) 4910079..4910795 + 717 WP_032434305.1 WYL domain-containing protein -
M5T34_RS23970 (4910831) 4910831..4911283 + 453 WP_032410767.1 hypothetical protein -
M5T34_RS23975 (4911355) 4911355..4911828 + 474 WP_032434303.1 hypothetical protein -
M5T34_RS23980 (4911948) 4911948..4912769 + 822 WP_032434301.1 DUF932 domain-containing protein -
M5T34_RS23985 (4912800) 4912800..4913240 + 441 WP_032434300.1 antirestriction protein -
M5T34_RS23990 (4913253) 4913253..4913795 + 543 WP_032434298.1 DNA repair protein RadC -
M5T34_RS23995 (4913806) 4913806..4914147 + 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T34_RS24000 (4914168) 4914168..4914509 + 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5T34_RS24005 (4914701) 4914701..4916734 - 2034 WP_050598589.1 hypothetical protein -
M5T34_RS24010 (4917325) 4917325..4918194 - 870 WP_023317468.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCTX-M-15 - 4878236..4928221 49985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T255461 WP_071994632.1 NZ_CP103550:4914168-4914509 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT255461 WP_032434296.1 NZ_CP103550:4913806-4914147 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References