Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4818289..4818805 Replicon chromosome
Accession NZ_CP103550
Organism Klebsiella pneumoniae strain 2791

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T34_RS23595 Protein ID WP_004178374.1
Coordinates 4818521..4818805 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5T34_RS23590 Protein ID WP_032434351.1
Coordinates 4818289..4818531 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T34_RS23575 (4814318) 4814318..4815058 + 741 WP_002886899.1 KDGP aldolase family protein -
M5T34_RS23580 (4815124) 4815124..4816278 + 1155 WP_002886900.1 lactonase family protein -
M5T34_RS23585 (4816301) 4816301..4818211 + 1911 WP_004152270.1 PRD domain-containing protein -
M5T34_RS23590 (4818289) 4818289..4818531 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T34_RS23595 (4818521) 4818521..4818805 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T34_RS23600 (4818809) 4818809..4819273 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T34_RS23605 (4819515) 4819515..4821653 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T34_RS23610 (4822010) 4822010..4822753 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T34_RS23615 (4822756) 4822756..4822929 - 174 WP_032414379.1 hypothetical protein -
M5T34_RS23620 (4823014) 4823014..4823322 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255460 WP_004178374.1 NZ_CP103550:4818521-4818805 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT255460 WP_032434351.1 NZ_CP103550:4818289-4818531 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References