Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4619736..4620439 Replicon chromosome
Accession NZ_CP103548
Organism Klebsiella pneumoniae strain 3987

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5T27_RS22485 Protein ID WP_071994632.1
Coordinates 4620098..4620439 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5T27_RS22480 Protein ID WP_032434296.1
Coordinates 4619736..4620077 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T27_RS22445 (4614891) 4614891..4615765 + 875 Protein_4381 GTPase family protein -
M5T27_RS22450 (4616009) 4616009..4616725 + 717 WP_032434305.1 WYL domain-containing protein -
M5T27_RS22455 (4616761) 4616761..4617213 + 453 WP_032410767.1 hypothetical protein -
M5T27_RS22460 (4617285) 4617285..4617758 + 474 WP_032434303.1 hypothetical protein -
M5T27_RS22465 (4617878) 4617878..4618699 + 822 WP_032434301.1 DUF932 domain-containing protein -
M5T27_RS22470 (4618730) 4618730..4619170 + 441 WP_032434300.1 antirestriction protein -
M5T27_RS22475 (4619183) 4619183..4619725 + 543 WP_032434298.1 DNA repair protein RadC -
M5T27_RS22480 (4619736) 4619736..4620077 + 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T27_RS22485 (4620098) 4620098..4620439 + 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5T27_RS22490 (4620631) 4620631..4622664 - 2034 WP_050598589.1 hypothetical protein -
M5T27_RS22495 (4623255) 4623255..4624124 - 870 WP_023317468.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4587142..4632720 45578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T255447 WP_071994632.1 NZ_CP103548:4620098-4620439 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT255447 WP_032434296.1 NZ_CP103548:4619736-4620077 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References