Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4527195..4527711 Replicon chromosome
Accession NZ_CP103548
Organism Klebsiella pneumoniae strain 3987

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T27_RS22095 Protein ID WP_004178374.1
Coordinates 4527427..4527711 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5T27_RS22090 Protein ID WP_032434351.1
Coordinates 4527195..4527437 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T27_RS22075 (4523224) 4523224..4523964 + 741 WP_002886899.1 KDGP aldolase family protein -
M5T27_RS22080 (4524030) 4524030..4525184 + 1155 WP_002886900.1 lactonase family protein -
M5T27_RS22085 (4525207) 4525207..4527117 + 1911 WP_004152270.1 PRD domain-containing protein -
M5T27_RS22090 (4527195) 4527195..4527437 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T27_RS22095 (4527427) 4527427..4527711 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T27_RS22100 (4527715) 4527715..4528179 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T27_RS22105 (4528421) 4528421..4530559 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T27_RS22110 (4530916) 4530916..4531659 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T27_RS22115 (4531662) 4531662..4531835 - 174 WP_032414379.1 hypothetical protein -
M5T27_RS22120 (4531920) 4531920..4532228 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255446 WP_004178374.1 NZ_CP103548:4527427-4527711 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT255446 WP_032434351.1 NZ_CP103548:4527195-4527437 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References