Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4042656..4043281 Replicon chromosome
Accession NZ_CP103548
Organism Klebsiella pneumoniae strain 3987

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M5T27_RS19785 Protein ID WP_002882817.1
Coordinates 4042898..4043281 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M5T27_RS19780 Protein ID WP_004150355.1
Coordinates 4042656..4042898 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T27_RS19755 (4038647) 4038647..4039246 + 600 WP_004151865.1 glucose-1-phosphatase -
M5T27_RS19760 (4039240) 4039240..4040100 + 861 WP_004146232.1 virulence factor BrkB family protein -
M5T27_RS19765 (4040097) 4040097..4040534 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M5T27_RS19770 (4040579) 4040579..4041520 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M5T27_RS19775 (4041534) 4041534..4042451 - 918 WP_009484979.1 alpha/beta hydrolase -
M5T27_RS19780 (4042656) 4042656..4042898 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M5T27_RS19785 (4042898) 4042898..4043281 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T27_RS19790 (4043455) 4043455..4044384 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M5T27_RS19795 (4044381) 4044381..4045016 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M5T27_RS19800 (4045013) 4045013..4045915 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T255444 WP_002882817.1 NZ_CP103548:4042898-4043281 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT255444 WP_004150355.1 NZ_CP103548:4042656-4042898 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References