Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3168631..3169288 Replicon chromosome
Accession NZ_CP103548
Organism Klebsiella pneumoniae strain 3987

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5T27_RS15485 Protein ID WP_002916310.1
Coordinates 3168631..3169041 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5T27_RS15490 Protein ID WP_002916312.1
Coordinates 3169022..3169288 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T27_RS15465 (3164631) 3164631..3166364 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
M5T27_RS15470 (3166370) 3166370..3167083 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T27_RS15475 (3167106) 3167106..3168002 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5T27_RS15480 (3168103) 3168103..3168624 + 522 WP_002916308.1 flavodoxin FldB -
M5T27_RS15485 (3168631) 3168631..3169041 - 411 WP_002916310.1 protein YgfX Toxin
M5T27_RS15490 (3169022) 3169022..3169288 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5T27_RS15495 (3169534) 3169534..3170517 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
M5T27_RS15500 (3170616) 3170616..3171275 - 660 WP_004174454.1 hemolysin III family protein -
M5T27_RS15505 (3171439) 3171439..3171750 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5T27_RS15510 (3171800) 3171800..3172528 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5T27_RS15515 (3172647) 3172647..3174080 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255441 WP_002916310.1 NZ_CP103548:c3169041-3168631 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255441 WP_002916312.1 NZ_CP103548:c3169288-3169022 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References