Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
| Location | 2938293..2938924 | Replicon | chromosome |
| Accession | NC_015848 | ||
| Organism | Mycobacterium canettii CIPT 140010059 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ28 |
| Locus tag | MCAN_RS13615 | Protein ID | WP_003413174.1 |
| Coordinates | 2938547..2938924 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ27 |
| Locus tag | MCAN_RS13610 | Protein ID | WP_014001327.1 |
| Coordinates | 2938293..2938550 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCAN_RS13575 | 2933611..2933925 | + | 315 | WP_015288321.1 | hypothetical protein | - |
| MCAN_RS13580 | 2934222..2935372 | + | 1151 | Protein_2669 | alpha/beta hydrolase family protein | - |
| MCAN_RS13585 | 2935499..2936158 | + | 660 | WP_014001324.1 | LppA family lipoprotein | - |
| MCAN_RS13590 | 2936155..2936814 | + | 660 | WP_014001325.1 | hypothetical protein | - |
| MCAN_RS13595 | 2936811..2937473 | + | 663 | WP_014001326.1 | hypothetical protein | - |
| MCAN_RS13600 | 2937470..2937748 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MCAN_RS13605 | 2937841..2938254 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| MCAN_RS13610 | 2938293..2938550 | + | 258 | WP_014001327.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| MCAN_RS13615 | 2938547..2938924 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MCAN_RS13620 | 2938940..2939314 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| MCAN_RS13625 | 2939414..2939809 | - | 396 | WP_014001328.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| MCAN_RS13630 | 2939806..2940051 | - | 246 | WP_014001329.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| MCAN_RS13635 | 2940462..2940881 | - | 420 | WP_014001330.1 | A24 family peptidase | - |
| MCAN_RS13640 | 2940893..2941702 | - | 810 | WP_014001331.1 | shikimate dehydrogenase | - |
| MCAN_RS13645 | 2941699..2942952 | - | 1254 | WP_014001332.1 | endolytic transglycosylase MltG | - |
| MCAN_RS13650 | 2942945..2943457 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T25544 WP_003413174.1 NC_015848:2938547-2938924 [Mycobacterium canettii CIPT 140010059]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T25544 NC_015848:2938547-2938924 [Mycobacterium canettii CIPT 140010059]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9396.54 Da Isoelectric Point: 10.3987
>AT25544 WP_014001327.1 NC_015848:2938293-2938550 [Mycobacterium canettii CIPT 140010059]
MRTQVTLGAEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGAEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT25544 NC_015848:2938293-2938550 [Mycobacterium canettii CIPT 140010059]
ATGCGGACTCAGGTGACCCTGGGCGCAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
GGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCGCAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
GGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|