Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1282272..1283860 Replicon chromosome
Accession NZ_CP103548
Organism Klebsiella pneumoniae strain 3987

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag M5T27_RS06220 Protein ID WP_004892016.1
Coordinates 1282538..1283860 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T27_RS06215 Protein ID WP_004176198.1
Coordinates 1282272..1282538 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T27_RS06190 (1277301) 1277301..1278224 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
M5T27_RS06195 (1278205) 1278205..1279359 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5T27_RS06200 (1279705) 1279705..1281084 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M5T27_RS06205 (1281062) 1281062..1281562 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5T27_RS06210 (1281559) 1281559..1281885 + 327 WP_004184023.1 hydroxyisourate hydrolase -
M5T27_RS06215 (1282272) 1282272..1282538 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T27_RS06220 (1282538) 1282538..1283860 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
M5T27_RS06225 (1283877) 1283877..1285169 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5T27_RS06230 (1285311) 1285311..1286315 - 1005 WP_032435338.1 fimbrial protein -
M5T27_RS06235 (1286303) 1286303..1288804 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T255435 WP_004892016.1 NZ_CP103548:1282538-1283860 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT255435 WP_004176198.1 NZ_CP103548:1282272-1282538 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References