Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2937841..2938550 Replicon chromosome
Accession NC_015848
Organism Mycobacterium canettii CIPT 140010059

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag MCAN_RS13605 Protein ID WP_003413164.1
Coordinates 2937841..2938254 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ27
Locus tag MCAN_RS13610 Protein ID WP_014001327.1
Coordinates 2938293..2938550 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCAN_RS13575 2933611..2933925 + 315 WP_015288321.1 hypothetical protein -
MCAN_RS13580 2934222..2935372 + 1151 Protein_2669 alpha/beta hydrolase family protein -
MCAN_RS13585 2935499..2936158 + 660 WP_014001324.1 LppA family lipoprotein -
MCAN_RS13590 2936155..2936814 + 660 WP_014001325.1 hypothetical protein -
MCAN_RS13595 2936811..2937473 + 663 WP_014001326.1 hypothetical protein -
MCAN_RS13600 2937470..2937748 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
MCAN_RS13605 2937841..2938254 + 414 WP_003413164.1 PIN domain nuclease Toxin
MCAN_RS13610 2938293..2938550 + 258 WP_014001327.1 ribbon-helix-helix domain-containing protein Antitoxin
MCAN_RS13615 2938547..2938924 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
MCAN_RS13620 2938940..2939314 - 375 WP_003413177.1 hypothetical protein -
MCAN_RS13625 2939414..2939809 - 396 WP_014001328.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
MCAN_RS13630 2939806..2940051 - 246 WP_014001329.1 type II toxin-antitoxin system antitoxin VapB20 -
MCAN_RS13635 2940462..2940881 - 420 WP_014001330.1 A24 family peptidase -
MCAN_RS13640 2940893..2941702 - 810 WP_014001331.1 shikimate dehydrogenase -
MCAN_RS13645 2941699..2942952 - 1254 WP_014001332.1 endolytic transglycosylase MltG -
MCAN_RS13650 2942945..2943457 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T25543 WP_003413164.1 NC_015848:2937841-2938254 [Mycobacterium canettii CIPT 140010059]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T25543 NC_015848:2937841-2938254 [Mycobacterium canettii CIPT 140010059]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9396.54 Da        Isoelectric Point: 10.3987

>AT25543 WP_014001327.1 NC_015848:2938293-2938550 [Mycobacterium canettii CIPT 140010059]
MRTQVTLGAEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT25543 NC_015848:2938293-2938550 [Mycobacterium canettii CIPT 140010059]
ATGCGGACTCAGGTGACCCTGGGCGCAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
GGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB G0TQ27

References