Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 12587..13134 Replicon plasmid pMB9029_2
Accession NZ_CP103546
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag M5S54_RS23820 Protein ID WP_244442846.1
Coordinates 12587..12865 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag M5S54_RS23825 Protein ID WP_000079941.1
Coordinates 12865..13134 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS23790 (7976) 7976..8860 - 885 Protein_10 hypothetical protein -
M5S54_RS23795 (9214) 9214..9816 + 603 WP_000517695.1 ProQ/FINO family protein -
M5S54_RS23800 (9872) 9872..10366 + 495 WP_001459505.1 hypothetical protein -
M5S54_RS23805 (10366) 10366..10632 + 267 WP_000955263.1 hypothetical protein -
M5S54_RS23810 (11109) 11109..11582 - 474 WP_001334658.1 hypothetical protein -
M5S54_RS23815 (11699) 11699..12547 - 849 WP_022630346.1 3'-5' exonuclease -
M5S54_RS23820 (12587) 12587..12865 - 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
M5S54_RS23825 (12865) 12865..13134 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
M5S54_RS23830 (13189) 13189..13347 - 159 WP_000841008.1 hypothetical protein -
M5S54_RS23835 (14043) 14043..15074 - 1032 WP_000907873.1 plasmid replication initiator RepA -
M5S54_RS23840 (16080) 16080..16310 + 231 WP_228772074.1 ash family protein -
M5S54_RS23845 (16228) 16228..16515 + 288 WP_000074849.1 conjugal transfer protein TraA -
M5S54_RS23850 (16957) 16957..17490 + 534 WP_001303319.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..98998 98998
- flank IS/Tn blaCMY-2 - 5062..7793 2731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T255428 WP_244442846.1 NZ_CP103546:c12865-12587 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT255428 WP_000079941.1 NZ_CP103546:c13134-12865 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References